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Dr. Benjamin N. Wadström and colleagues (Herlev and Gentofte Hospital, Herlev, Denmark) highlighted an association between remnant cholesterol and risk for peripheral artery disease (PAD). High remnant cholesterol is already recognised as a risk factor for ischaemic heart disease and ischaemic stroke (1,2); however, whether it is also implicated in PAD is not known. Using data from over 100,000 people in the Copenhagen General Population Study, as well as nearly 14,000 people in the Copenhagen City Heart Study, investigators showed that higher levels of remnant cholesterol associated with increased risk for PAD. In particular, people with levels above ≥1.5 mmol/L had a 5-fold risk of clinical PAD compared with those with low levels. The findings of this study are important as people with PAD are at very high risk of cardiovascular events, but are typically undertreated (3). Remnant cholesterol, the cholesterol contained in triglyceride-rich lipoproteins and their remnants, appears to be another risk factor to be targeted to reduce this risk. [Rapid Fire Session Clinical. Monday May 31] Available on demand
Dr. Wadström discusses the study here:
- Varbo A, Benn M, Tybjærg-Hansen A, et al. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol 2013;61:427-36.
- Varbo A, Nordestgaard BG. Remnant cholesterol and risk of ischemic stroke in 112,512 individuals from the general population. Ann Neurol 2019;85:550-9.
- Reinecke H, Unrath M, Freisinger E, et al. Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence. Eur Heart J 2015;36:932-8.
Dr. Federico Oldoni (University of Texas Southwestern Medical Center, Dallas, USA) discussed determinants of plasma angiopoietin-like protein (ANGPTL)8 levels. Using the Dallas Heart Study database, a large multi-ethnic population-based cohort, Dr. Oldoni showed that distribution of fasting ANGPTL8 levels were skewed to the right, with differences according to racial/ethnic group. The ANGPTL8 variant (59W) explained ~17% of the inter-individual variation in plasma levels but was not associated with any of the metabolic parameters correlated with plasma ANGPTL8 concentration. He concluded that ANGPTL8 levels were a consequence of the associated metabolic phenotypes. [Rapid Fire Session Clinical. Monday May 31] This session is available to view on demand
Dr. Samuli Ripatti and colleagues (University of Helsinki, Finland, and Broad Institute, Cambridge, USA) developed a novel risk score by combining genome-wide information with lifestyle factors and comorbidities obtained by questionnaires and 10-year risk of incident coronary heart disease using FinnGen. This risk calculator had similar or better performance compared to current disease risk calculators that require blood tests and in-person medical appointments. [ID:1015] This lecture is available on demand
Dr. Emilie Kjeldsen (University of Copenhagen, Denmark) investigated the role of dietary adherence in preventing dementia. Targeting the major established risk factors, including high blood pressure, high cholesterol, diabetes and smoking, with diet and pharmacotherapy is important. In contrast, patients who do not adhere to dietary guidelines may be at increased risk of vascular dementia, according to this study using data from the Copenhagen General Population Study. [WORKSHOP: DIET AND CVD] This presentation is available on demand
More News from the Sessions
Workshop: Diet and CVD. Professor Jane Armitage discusses the evolving story of omega-3 trials and reduction of cardiovascular risk [WORKSHOP: DIET AND CVD] This presentation is available on demand.
IAS/EAS Joint session: Universal cardiovascular health – time to act
- Antonio Vallejo-Vaz (Imperial College London, UK) discusses implications of the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) To guiding global policy on FH
- Cristina Taddei (Imperial College London, UK) discusses implications of recent findings from the NCD Risk Factor Collaboration (NCD-RisC)
- Noor Al Busaidi (National Diabetes Center, Muscat, Oman) asks whether there is a gender issue relating to the impact of obesity on cardiovascular disease
- View this session on demand
NLA/EAS Joint session. Women, atherosclerosis and lipids: What is different. Dr Jeanine Roeters van Lennep (Erasmus University, Rotterdam, the Netherlands) discusses gender-specific risks in women [see on demand]
Session: Lifestyle and prevention: Secrets to success. Dr Benoit Arsenault (Amsterdam UMC, the Netherlands) discusses how to define success in lifestyle intervention [see on demand]
Session: Atherosclerosis in ageing societies. Dr Martin Mortensen (Aarhus University Hospital, Aarhus Denmark) discusses primary prevention in ageing societies [see on demand]